Ph.D. Vice President, DMPK
John Scott Daniels

I am a drug metabolism & pharmacokinetics (DMPK) scientist with a decade of experience within the pharmaceutical industry before arriving at Vanderbilt.  I have extensive experience in discovery and development DMPK (Ph1-Ph3, Ph4 evaluation) with research interests in drug metabolism, specifically in novel biotransformations that deactivate pharmacophores and mediate drug-induced organ toxicity.  I have published in areas of DNA adduct formation, drug metabolism and disposition, novel biotransformations and metabolism-mediated toxicity through novel pharmacological mechanisms.  The extent of my laboratory’s DMPK experimental prowess ranges from in vitro and in vivo pharmacokinetics and efflux of small molecule drug candidates to investigating the role of metabolism in mediating bioactivation and drug-mediated toxicity.  I am fully confident that I can accomplish the stated goals and DMPK needs for the research project.  Our laboratory maintains a mass spectrometry suite for high throughput bioanalysis and metabolite structure elucidation.  I am the Director of Drug Metabolism and Pharmacokinetics for the Vanderbilt Center for Neuroscience Drug Discovery, and hold appointments as Assistant Professor in the Department of Pharmacology and the Department of Medicine. 

Positions and Honors
Employment

2000 -2001 Research Scientist, DuPont Pharmaceuticals, Co., Newark, DE
2001 - 2002 Senior Research Scientist, DuPont Pharmaceuticals, Co., Newark, DE
2002  Senior Scientist, Pfizer, Inc., Ann Arbor, MI
2002 - 2003  Principal Scientist, Millennium Pharmaceuticals, Inc., Cambridge, MA
2003 - 2006          Senior Scientist I, Millennium Pharmaceuticals, Inc., Cambridge, MA
2004 - 2006          Adjunct Professor, Massachusetts College of Pharmacy, Boston, MA
2006 - 2009      Senior Principal Scientist, Pfizer, Inc., St. Louis, MO
2009 - 2010          Associate Research Fellow, Pfizer, Inc., St. Louis, MO
2010 - Present          Director of Drug Metabolism and Pharmacokinetics, Vanderbilt Center for Neuroscience Drug Discovery, Assistant Professor of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN
2014 - Present  Vice President, Drug Metabolism and Pharmacokinetics, VDDI Pharmaceuticals
2014-present     Member, Scientific Advisory Board and Consultant VDDI Pharmaceuticals